Credit: Geoffrey Lewis

NRI stem cell investigators work at the interface of molecular cell biology and bioengineering. These investigations run the gamut from basic investigations providing unique insights into the development of the nervous system to probing the onset of neurodegenerative diseases to clinical trials in which stem cells are being used to generate replacement cells for neurodegenerative conditions such as retinitis pigmentosa and age related macular degeneration.


Wilcox Family Chair in BioMedicine
Dr Clegg's research focuses on developing cures for blindness using embryonic, iPS, and adult stem cells.
Two major groups of diseases termed retinitis pigmentosa and age-related macular degeneration are the leading causes of blindness.
Assistant Professor
The goal of our lab is to develop novel single-cell sequencing technologies to understand how variability in the epigenome regulates gene expression heterogeneity and cell fate decisions.
Professor Emeritus
Structure and function in the vertebrate retina with an emphasis on mechanisms underlying photoreceptor degeneration and the role of glial cells in normal and injured or diseased retina.
Co-Director NRI
Harriman Professor of Neuroscience
Neural plasticity including the molecular basis of plasticity, the evolution of synapses, and disease-related impairments of plasticity such as occurs in Alzheimer's disease.
My current research involves developing treatment strategies for diseases and injuries of the retina.
Duggan Professor and Distinguished Professor
Combination of molecular, genetic, and state-of-the-art imaging approaches to define and solve fundamental questions in cell and developmental biology with implications for neurodegenerative disease, ischemic diseases and cancer.
Molecular and genetic analysis of development, stem cell biology, apoptosis, and behavior in the nematode C. elegans.
Dr. Thomson's research areas of focus are differentiation of vascular progenitors for transplantation therapies and mammalian developmental clocks.
Prof. Valentine’s research focuses on the mechanics of cells and tissues and the design of bio-inspired materials.
Assistant Professor
Combines tools from Biology, Engineering, and Physics to understand the cell’s perceptual field.