Credit: Geoffrey Lewis

NRI stem cell investigators work at the interface of molecular cell biology and bioengineering. These investigations run the gamut from basic investigations providing unique insights into the development of the nervous system to probing the onset of neurodegenerative diseases to clinical trials in which stem cells are being used to generate replacement cells for neurodegenerative conditions such as retinitis pigmentosa and age related macular degeneration.

Researchers

Dennis Clegg

Professor
Wilcox Family Chair in BioMedicine
Dr Clegg's research focuses on developing cures for blindness using embryonic, iPS, and adult stem cells.
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells
The Visual System

Peter Coffey

Researcher
Two major groups of diseases termed retinitis pigmentosa and age-related macular degeneration are the leading causes of blindness.
Alzheimer’s Disease & Related Dementias
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells
The Visual System

Siddharth Dey

Assistant Professor
The goal of our lab is to develop novel single-cell sequencing technologies to understand how variability in the epigenome regulates gene expression heterogeneity and cell fate decisions.
Stem Cells
Tools & Technology Development

Adele Doyle

Assistant Professor
Neural & cardiovascular tissue engineering/regenerative medicine. Stem cells, mechanobiology, molecular control systems.
Alzheimer’s Disease & Related Dementias
Cell Biology, Biochemistry & Biophysics of the Nervous System
Computational & Theoretical Neuroscience
Development of the Nervous System
Stem Cells
Systems Neuroscience & Imaging Neural Activity
Tools & Technology Development

Steven Fisher

Professor Emeritus
Structure and function in the vertebrate retina with an emphasis on mechanisms underlying photoreceptor degeneration and the role of glial cells in normal and injured or diseased retina.
Cell Biology, Biochemistry & Biophysics of the Nervous System
Stem Cells
The Visual System

Kenneth Kosik

Co-Director NRI
Harriman Professor of Neuroscience
Neural plasticity including the molecular basis of plasticity, the evolution of synapses, and disease-related impairments of plasticity such as occurs in Alzheimer's disease.
Alzheimer’s Disease & Related Dementias
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells
Tools & Technology Development

Geoff Lewis

Researcher
My current research involves developing treatment strategies for diseases and injuries of the retina.
Stem Cells
The Visual System

Denise Montell

Duggan Professor and Distinguished Professor
Combination of molecular, genetic, and state-of-the-art imaging approaches to define and solve fundamental questions in cell and developmental biology with implications for neurodegenerative disease, ischemic diseases and cancer.
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells

Monte Radeke

Project Scientist
Add Research Teaser.
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells
The Visual System

Joel Rothman

Professor
Molecular and genetic analysis of development, stem cell biology, apoptosis, and behavior in the nematode C. elegans.
Alzheimer’s Disease & Related Dementias
Behavioral Neuroscience & Neuroethology
Cell Biology, Biochemistry & Biophysics of the Nervous System
Development of the Nervous System
Stem Cells

James Thomson

Professor
Dr. Thomson's research areas of focus are differentiation of vascular progenitors for transplantation therapies and mammalian developmental clocks.
Stem Cells

Megan Valentine

Professor
Prof. Valentine’s research focuses on the mechanics of cells and tissues and the design of bio-inspired materials.
Alzheimer’s Disease & Related Dementias
Cell Biology, Biochemistry & Biophysics of the Nervous System
Stem Cells
Tools & Technology Development

Max Wilson

Assistant Professor
Combines tools from Biology, Engineering, and Physics to understand the cell’s perceptual field.
Stem Cells
Tools & Technology Development