Mapping specific sensory features to future motor actions is a crucial capability of
mammalian nervous systems. We investigated the role of visual (V1), posterior parietal (PPC), and
frontal motor (fMC) cortices for sensorimotor mapping in mice during performance of a memoryguided
visual discrimination task. Large-scale calcium imaging revealed that V1, PPC, and fMC
neurons exhibited heterogeneous responses spanning all task epochs (stimulus, delay, response).
Mucolipidosis IV (MLIV) is a devastating early childhood neurological disease characterized by progressive neurodegeneration, leading to severe impairments in muscle coordination, cognitive deficits and retinal degeneration that causes blindness.
Medical research has yet to discover an Alzheimer’s treatment that effectively slows the disease’s progression, but neuroscientists at UC Santa Barbara may have uncovered a mechanism by which onset can be delayed by as much as 10 years.
That mechanism is a gene variant — an allele — found in a part of the genome that controls inflammation. The variant appears to prevent levels of the protein eotaxin from increasing with age, which it usually does hand in hand with inflammation. The findings appear in the journal Molecular Psychiatry.